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Undergrad and Radcliffe fellow bond over bones

first_imgLast year, while walking through campus, Linh Nam ’20 felt something in her leg buckle.A survivor of osteosarcoma, the most common type of bone cancer, she had a bone graft to save her knee when she was 10 years old; now, just 10 years later, the metal plate meant to reinforce the new bone had failed due to years of bearing her weight. Nam was offered two choices: try another bone graft — this time vascularized, or infused with her own blood vessels, to further encourage bone growth — or undergo a total knee replacement.“The doctor said the knee replacement would have to be repeated every 10 years,” Nam says. “If I lived to be 80, I’d need seven of them.” She has already had 10 surgeries since her diagnosis due to complications.She opted for a new graft with bone harvested from her tibia — the last chance at salvaging her original knee. Although there have been signs of bone growth since her December surgery, the site has not completely healed, and Nam has spent the months since on crutches.While looking for a summer job after her second year at the College, Nam came across a listing on the student employment website for a summer Radcliffe Research Partnership.Seeking student assistance was Professor Hala Zreiqat, RI ’17, a biomedical engineer who had returned to the Radcliffe Institute as a summer fellow to continue research on a project titled “3D Printing of Ceramics Using Advanced Layer by Layer Technologies’ Medical Devices.”“When I read the description, I thought, ‘Wow, this is quite relevant, given my experience,”’ said Nam, a human evolutionary biology concentrator. She applied.Zreiqat, for her part, noted that there was an applicant with a history of osteosarcoma — but it was Nam’s scientific background that ultimately won her an interview. It was only when the student arrived at the meeting on crutches that Zreiqat made the connection. “I thought, ‘My goodness, that’s the one with osteosarcoma.’” A personal and layered scientific match was made.Zreiqat has herself experienced the limitations of the clinically available bone substitutes (she once traveled to Germany from Australia to undergo a procedure in which bone was harvested from her mandible). She has also seen family members faced with the prospect of multiple joint replacements over the course of a lifetime. Her team at the University of Sydney’s Biomaterials and Tissue Engineering Research Unit has developed a 3-D-printed bone substitute out of a ceramic-based material, one they hope will mean better treatment options for people who suffer bone loss.,When harvesting bone from a patient’s own body, a much larger sample is taken than the injury site requires, so the supply is naturally limited. Other options include donor bone — usually from a cadaver — whose structural integrity has been compromised during processing, such as by irradiation. The last option is metal, which, while strong, does eventually wear down.The bone substitutes developed by Zreiqat and her lab are a much-needed additional option for patients who have bone defects: nontoxic, strong, and stable, they also encourage growth in the patient’s own bone, negating the need for metal implants.Zreiqat thinks that her 3-D-printed implants could reach the public as early as 2019, but while she waits, she continues to innovate 3-D-printed medical devices with other musculoskeletal applications. And Nam? She wants to ensure that no one else has to endure what she did and is now planning to study medicine.The Radcliffe Institute is accepting applications for the 2018‒19 Radcliffe Research Partnership program. To apply or for more information, visit the program’s website.last_img read more

Inquiry finds no ‘actionable’ sexual bias at United Way

first_imgAn investigation into harassment allegations by three former employees of United Way Worldwide found no evidence of “actionable harassment, discrimination, or retaliation,” although the report urged the organization to review and improve its policies regarding such complaints, according to a statement issued by the nonprofit. Three female former employees filed complaints over the past two years with the Equal Employment Opportunity Commission saying the organization retaliated against them for speaking up about sexual misconduct. After the allegations were raised internally, two of the women were fired and United Way Worldwide’s CEO, Brian Gallagher, unsuccessfully sought to terminate the third, according to HuffPost.last_img read more

Lessons of the Week! Neil Patrick Harris, Miss Piggy & More

first_imgIt’s Friday, and there’s nothing like hitting the town curling up on the couch and catching up on the craziest Broadway news of the week! We learned a lot of weird stuff about Sutton Foster, Kristin Chenoweth, Darren Criss and more of our favorite stars over the last few days. But don’t take our word for it—check ‘em out below.Sutton Foster Is a Rap SuperstarTony winner Sutton Foster is great at belting, tap dancing, makeovers and makeunders, but did you know she’s also got street cred? The Younger star said she’d love to appear in a hip-hop musical by Lin-Manuel Miranda and even gave us a few bars of In the Heights to prove it. No me diga!David Burtka Sees Dead PeopleIf you asked us what It Shoulda Been You is like, we might say it’s kinda like My Best Friend’s Wedding, but way crazier. David Burtka, on the other hand, says it’s more like The Sixth Sense. Oh right, we forgot about that scene when Room Sheep glides in on her scooter and announces David Burtka is a ghost. Baa.NPH Won’t Suit Up For the TonysMore news from the Burtka-Harris household—sadly, after hosting the Tony Awards four times, Neil Patrick Harris told he will not be hosting the Tony ceremony this year, and he’d rather devote the time to developing his new variety show. No Tony rap? No Mormon outfit? No car wash!? Sigh.Everyone Wants to Shag Miss PiggyWhen we hit the red carpet on opening night of Hand to God to ask stars which puppet they’d like to have sex with, they were surprisingly forthcoming with their answers. Oddly, Justin Bartha, Reed Birney, Patrick Page and Robert Askins all chose Miss Piggy as their puppet crush. Watch out, Kermie.Kristin Chenoweth Is an Evian DivaAccording to her dresser Maureen Leshley, On the Twentieth Century star Kristin Chenoweth is extremely lovely, sweet and fun to work with. She’s only “cray cray” about two things: Using the term “cray cray” and her water bottles. Kristin dearest, you got it—from now on, no plastic water bottles EVER!Darren Criss STILL Has a BeardEven though his promo photos would suggest otherwise, it seems Darren Criss has misplaced his razor. The new Hedwig star is in the throes of rehearsal, but at the Finding Neverland opening, we noticed he’s still hanging out to his scraggly beard. Hey Darren, do you have xyrophobia or something? Why don’t you come over to HQ and shave it on Live at Five? We have peanut butter cups.Throw Your Shoes at Gloria EstefanOn Your Feet! co-creator Gloria Estefan hopes audience members have so much fun at her new musical that they throw their shoes up in the air and do that conga in the aisles. That sounds so fun! Well, as long as it’s not these shoes.Santino’s Hanging on the Block With JennyTony nominee Santino Fontana is about to become a TV star! The Cinderella and Frozen favorite will play a cop opposite Jennifer Lopez in the new NBC drama Shades of Blue. Hey Santino, wasn’t J-Lo your childhood crush? Oh wait, no, it was waffles. Our mistake. Well, maybe one day you can do an Eggo commercial.Kelli Barrett Wants a B’way ThreesomeDoctor Zhivago stars Tam Mutu and Kelli Barrett have two very different ideas about what should happen in a dinner party between the Phantom, Javert and Zhivago. Tam thinks they should have a nice Bordeaux or perhaps a Barolo. Kelli thinks they should all make out. #TeamKelli.Don’t Invite Megan Hilty to Your WeddingOn opening night of wedding-themed musical It Shoulda Been You, we asked Megan Hilty and her husband Brian Gallagher if they brought a gift to the nuptials. They shrugged, said they got married in Vegas and they’re “those guests.” Not even a $5.95 plastic colander? Not even Wicked napkin rings?! We can’t take you guys anywhere. View Commentslast_img read more

AES Gener plans 863MW wind-solar-storage project in Chile

first_img FacebookTwitterLinkedInEmailPrint分享Renewables Now:Santiago-based power company AES Gener SA submitted in Chile the environmental impact statement (EIS) for the 863-MW Parque Terra Energia Renovable wind-and-solar hybrid project.According to documents sent to the Chilean environmental evaluation service (SEA), the South American firm plans to invest USD 750 million (EUR 634.6m) in the project through its unit Energia Eolica Paposo SpA.Located in the commune of Taltal in Antofagasta, Parque Terra will consist of a 350-MW wind farm, with 50 turbines of 7 MW each, and a 513-MW solar park comprised of 1,102,080 bifacial panels mounted on trackers. It will also have battery storage capacity.The project is expected to break ground in the second quarter of 2022 with commissioning scheduled to take place during the first half of 2024.[Lucas Morais]More: AES Gener files EIS for 863-MW renewables project in Chile AES Gener plans 863MW wind-solar-storage project in Chilelast_img read more

FICO adds consideration of account activity to the credit scoring mix

first_imgGreetings credit union people, with a special shout-out to the attendees of the Volunteer’s Conference.What has caught my eye this morning is this article from the Wall Street Journal reporting that Fair Isaacs is rolling out a significant addition to its FICO credit score system. It’s the latest example of how big data analytics has the potential to remake traditional lending model as statisticians get a better feel for how non-traditional consumer attributes can be used to predict whether someone is a good or bad credit risk.Starting next year, the company will start offering the “UltraFICO Score.” According to the Wall Street Journal, the Pentagon Credit Union is going to be the first users of this new framework. With a consumer’s consent, FICO will now consider a consumer’s checking and savings account transaction history as part of the process of generating a person’s credit score. According to the company, the product will be used as an option for consumers who do not have a sufficient credit history to be “score-able” or who want to recalibrate their existing credit score if they are near credit score cutoffs. continue reading » 5SHARESShareShareSharePrintMailGooglePinterestDiggRedditStumbleuponDeliciousBufferTumblrlast_img read more

Healthcare Systems Offer Expert Breast Cancer Care to Long Islanders

first_imgSign up for our COVID-19 newsletter to stay up-to-date on the latest coronavirus news throughout New York Between 2012 and 2016, there were 13,064 new cases of female breast cancer in Nassau and Suffolk counties, according to the U.S. Centers for Disease Control and Prevention. In response, New York State and Long Island healthcare systems continue to raise the bar in care and treatment for patients facing a breast cancer diagnosis, enhancing their approach from an emotional, physical, and physiological perspective and making it more accessible overall. To date, most healthcare systems have embraced a multidisciplinary approach to treating breast cancer, as well as innovative practices to improve their patients’ outcomes.“It’s easier to share information and sharing information leads to more consistency and higher quality care,” says Dr. Brian O’Hea, director of the Carol M. Baldwin Breast Care Center in Stony Brook.As an academic medical center, Stony Brook has access to the most current clinical trials, in addition to standard of care, he says. “We also have a radiation oncology team looking for ways to treat patients successfully with less radiation treatments,” he says, noting that the goal is “patient-centered and patient-focused care.” Dr. O’Hea was the first fellowship-trained breast surgeon on Long Island. “Breast cancer surgery was [initially] mixed in with hernia and gall bladder surgery,” he says. “The advent of breast fellowships and specially trained breast surgeons trained on the technical aspects of breast cancer surgery, and also including adjuvant therapies, was a huge innovation for women.”Stony Brook was also the first in New York State to receive accreditation from the National Accreditation Program for Breast Centers (NAPBC), he notes.Going forward, Stony Brook remains committed to research, for example, “looking for better imaging of the armpit lymph nodes to see whether there is cancer or not using a special MRI coil,” Dr. O’Hea says.The center isn’t alone in its innovation. South Nassau Communities Hospital in Oceanside recently partnered with Mount Sinai to become Mount Sinai South Nassau. “We are pleased to be the flagship hospital for Mount Sinai,” says Dr. Christine Hodyl, director of breast services at Mount Sinai South Nassau. “All of the components are here in the hospital, with less travel and having expertise in breast cancer care in a patient’s own backyard.” Mount Sinai is embracing new approaches to breast cancer surgery, utilizing oncoplastic techniques. “We provide the most innovative surgical techniques that have excellent cosmetic results and improve the functional quality for a patient,” Dr. Hodyl says. For example, “We are now placing implants above the muscle and we are able to do an immediate implant reconstruction at the same time as a mastectomy, leaving the muscle in place; and this leads to less pain, quicker recovery and a smaller number of surgical procedures.”Mount Sinai is also adding genetic testing programs, genetic counselors, and nurse navigation to its protocol in order to best serve patients with breast cancer.NYU Langone Medical Center and Winthrop-University Hospital in Mineola united several years ago to enhance their healthcare networks on Long Island. Good Samaritan Hospital in West Islip is opening its new 25-square-foot cancer center in October.“We are able to provide the same kind of care that is provided at NYU Langone at the Perlmutter Cancer Center on Long Island,” says Dr. Nina D’Abreo, medical director for Breast Health at Perlmutter Cancer Center at NYU Winthrop. Perlmutter aims to improve the multidisciplinary approach to breast cancer care and breast cancer survivorship. Dr. D’Abreo chairs an annual breast health symposium committed to offering up-to-date care and the latest innovations “right from prevention to survival,” she says. This includes everything from education and screening to social work and navigation to research and advanced treatments.Perlmutter has dedicated breast surgeons who are skilled in minimally invasive techniques for breast surgery-reducing lymph node surgery, as well as Savi Scout technology, which uses radar technology to guide a surgeon and target breast tissue during a lumpectomy or biopsy procedure, Dr. D’Abreo notes. Perlmutter helped pioneer prone breast radiation therapy, which minimizes radiation damage to the lungs and the heart, she adds.The Perlmutter Center is researching immune therapy for triple negative breast cancer, participating in local and national clinical trials, says Dr. D’Abreo. Located in Uniondale, Memorial Sloan Kettering Nassau offers expert cancer care including chemotherapy, immunotherapy and radiation — with greater convenience for Long Islanders.  “At Memorial Sloan Kettering, we have many clinical trials that are available to patients in all stages of breast cancer treatment both up front, as well as clinical trials that have cutting-edge therapies for metastatic disease,” says Dr. Tiffany Troso-Sandoval, board-certified medical oncologist at Memorial Sloan Kettering. “The role of DNA molecular profiling gives a more comprehensive understanding of the DNA mutations that contribute to the cancers’ function,” she says. “This test is run on every patient that has recurring or metastatic cancer. Results are placed in a databank shared with physicians and patients so if a clinical trial should arise and a patient has that same gene, our computers will pick that up immediately.” “MSK is considered to be one of the top organizations with cutting-edge evaluation and therapy for breast cancer,” she continues. “Our facility at Nassau has full-time social work, nutrition, and physical therapy, in addition to layers of supportive nursing and multiple subspecialty positions to help support the patients physically and emotionally.”Northwell Health is committed to assuring that “patients are better informed, more supported and experience a better journey when they’re diagnosed,” says Dr. Karen Kostroff, chief of breast surgery at Northwell Health. Northwell’s cancer centers throughout Long Island — including Huntington, Great Neck and the Imbert Cancer Center in Bay Shore — make expert care accessible and offer everything from screening and diagnosis to surgery to posttreatment, which includes a breast survivorship program. Northwell’s multidisciplinary team allows for consultation and discussion to ascertain an appropriate plan of treatment for individual breast cancer patients. Treatment could include radiation, chemotherapy, surgery, etc., however, there is no one-size-fits-all approach, explains Dr. Kostroff, noting that genetic history and testing is also valued.Dr. Kostroff leads a systemwide tumor board that addresses patients whose cancer is uniquely “challenging and complicated.” This forum includes 12 sites throughout the Northwell system. “All of these physicians are learning and discussing — sharing updated information on new clinical trials and education,” she explains. “We are also involved in a tumor donation program, where instead of the tissue being discarded once it’s studied, it is given to Cold Spring Harbor Laboratories so they to can research on a fresh tumor.”With Northwell Health’s Center for Wellness and Integrative Medicine, “patients can also focus on taking care of their bodies through programs such as reiki, Pilates, massage and more,” says Dr. Kostroff. Catholic Health Services offers patients diagnosed with breast cancer treatment and services throughout Long Island. CHS’ six hospitals include Good Samaritan Hospital Medical Center in West Islip, Mercy Medical Center in Rockville Centre, St. Catherine of Siena Medical Center in Smithtown, St. Charles Hospital in Port Jefferson, St. Francis Hospital The Heart Center in Roslyn, and St. Joseph Hospital in Bethpage. CHS offers early detection and imaging services, utilizes minimally invasive techniques for breast disease, and also provides genetic counseling for individuals who have an increased risk for breast cancer. Education and support groups are offered to ensure patients are provided with emotional as well as physical care. Like the majority of, if not all healthcare systems, CHS also embraces a multidisciplinary approach to breast cancer.last_img read more

Thailand reports 25th H5N1 case

first_imgSep 26, 2006 (CIDRAP News) – Thailand reported its 25th H5N1 avian influenza case today, a fatal illness in a 60-year-old man who raised fighting roosters.The man was from Bong Bua Lamphu province, about 379 miles northeast of Bangkok, and died on Aug 10, according to a Bloomberg News report today. Praj Boonyawongwirojana, the health ministry’s permanent secretary, told reporters that samples from the man were taken 2 days later and that his diagnosis was confirmed 4 days ago.If the World Health Organization (WHO) confirms the man’s case, the global H5N1 count will rise to 250 cases with 147 deaths. The case marks the 17th H5N1 death in Thailand and the country’s third case of 2006. After a nearly 8-month lull, the first case this year was confirmed on Jul 26. All three Thai cases this year have been fatal.Thai disease control minister Thawat Suntrajarn told Bloomberg News that though the man had the H5N1 virus, his death was caused by complications from a bacterial infection. Repeated tests were needed to confirm that he had avian flu.The patient was treated with the antiviral medication oseltamivir when doctors suspected he might have avian flu, the Bloomberg article notes.Thawat said the man had been exposed to dead chickens. “It took about 14 days after he fell sick before he admitted to having contact with dead chickens. He loved his fighting cocks so much that he didn’t want the authorities to kill his surviving birds if he reported a large number of dead chickens,” he said.According to Bloomberg, fighting cocks used in gambling bouts in Thailand are worth as much as 500,000 baht ($13,369).Agence France-Presse reported today that Thailand’s military, which seized control of the government in a bloodless coup last week, has asked public health officials to report avian flu cases in a timely manner.Meanwhile in Indonesia, health officials are investigating a possible avian flu case cluster involving three siblings, one of whom died, according to a Reuters report today. The patients are from West Java province.The oldest, a 25-year-old man, died 2 days ago at a hospital in Bandung, West Java’s capitol. His 20-year-old brother and 15-year-old sister are hospitalized. Hadi Yusuf, head of the avian flu ward at Hasan Sadikin hospital, told Reuters that the surviving brother tested positive for the H5N1 virus and is on a ventilator. Test results from the sister are expected tomorrow, he said.Yusuf said it’s not clear if samples were taken from the brother who died.The brothers had a history of contact with dead chickens, which they bought to feed their dog. However, Yusuf told Reuters that the girl had no known contact with chickens. “We need to suspect she got it from the brothers,” he said.last_img read more

Retail: Setting up shop

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Talk of the towns

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Lille president confirms Nicolas Pepe’s move to Arsenal and reveals transfer fee

first_imgAdvertisement Lille president confirms Nicolas Pepe’s move to Arsenal and reveals transfer fee Metro Sport ReporterWednesday 31 Jul 2019 5:54 pmShare this article via facebookShare this article via twitterShare this article via messengerShare this with Share this article via emailShare this article via flipboardCopy link7kShares Pepe impressed with 22 goals and 11 assists for Lille last term (Picture: Getty)Earlier this week, a member of Pepe’s entourage explained just how close the attacker came to joining Napoli before Arsenal’s ‘sporting project’ won him over.‘After meeting and discarding several clubs, Nicolas Pepe was able to choose between Naples and Arsenal,’ one of Pepe’s close associates told Ivorian publication Sport Mania.‘I won’t lie to you: a total agreement was almost reached with Napoli.‘But Arsenal’s offer was more convincing, both financially and in terms of the sporting project.’More: FootballBruno Fernandes responds to Man Utd bust-up rumours with Ole Gunnar SolskjaerNew Manchester United signing Facundo Pellistri responds to Edinson Cavani praiseArsenal flop Denis Suarez delivers verdict on Thomas Partey and Lucas Torreira movesPepe will be the fourth player to join Arsenal this summer following the arrivals of Gabriel Martinelli, Dani Ceballos (loan) and William Saliba.Saliba, though, who joined Arsenal for a fee of around £27m, has been loaned back to Saint-Etienne for the 2019/20 campaign.MORE: Brendan Rodgers denies rumours that Manchester United are close to signing Harry Maguire Comment Nicolas Pepe will join Arsenal for a fee of around £73m (Picture: Getty)Lille president Gerard Lopez has confirmed Arsenal’s club-record €80million (£73m) move to sign Nicolas Pepe.Arsenal are expected to announce Pepe’s arrival in the coming hours and the 24-year-old forward will reportedly agree to a five-year contract at the Emirates.Unai Emery has been desperate to add a winger to his squad this summer and after Arsenal’s £40m bid for Wilfried Zaha was rejected, the club turned to Pepe, a player who took Ligue 1 by storm last season.Napoli also registered a strong interest in Pepe, but the Ivorian opted instead to join the Gunners to become the most expensive African footballer in the history of the game.AdvertisementAdvertisementADVERTISEMENTMore: FootballRio Ferdinand urges Ole Gunnar Solskjaer to drop Manchester United starChelsea defender Fikayo Tomori reveals why he made U-turn over transfer deadline day moveMikel Arteta rates Thomas Partey’s chances of making his Arsenal debut vs Man CityOn Wednesday evening, Lille president Lopez confirmed Pepe’s departure and revealed that Arsenal will make an official announcement over his arrival imminently.‘He is the one who made the decision, I think it should be [made official] in the next 24 hours,’ Lopez told French outlet RMC Sport.‘It is €80m fixed. If we pushed this deal out a little bit longer, we could have had five or six offers of the same size.‘Through discussions with Nico and his agents, the situation focused on the certain clubs that we wanted to focus on: the two projects that interested the player.’ Advertisementlast_img read more